There is no doubt that anti-virus is important for your computer. Fortunately, while doing this process, no settings, files, or applications will be removed. So, run a Repair or Office Diagnostics to solve this issue. Outlook 2010 signature not opening after the last time you used it means an installation error could be a problem. Make sure you are using the right server settings if Outlook is not opening emails. A wrong configuration may cause Outlook not to open. If you are using Outlook for the first time, you need to configure your email account correctly. You need to check the program that might keep Outlook running so that you can stop it. This is because Outlook might already be running even if you can't see it.
These are invisible to you, but when they are running, trying to open Outlook ends up in failure. Outlook usually leaves some processes running in the background.
